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Laparoscopic Nephrectomy Using the EnSeal Tissue Sealing and Hemostasis System |
Independent peer reviewed journal article, published in Journal of the Society of Laparoendoscopic Surgeons: Laparoscopic nephrectomy using the EnSeal Tissue Sealing and Hemostasis System: successful therapeutic application of nanotechnology. Smaldone, Marc C; Gibbons, Erin P; Jackman, Stephen V., Dept of Urology, University of Pittsburgh School of Medicine. (JSLS, Journal of the Society of Laparoendoscopic Surgeons, Volume 12, Number 2, April-June 2008 , pp. 213-216(4))
Independent case report on the application of EnSeal in the field of vessel sealing for urology. Report on the initial experience of the use of EnSeal for laparoscopic nephrectomy.
Conclusion: initial experience with EnSeal shows that it can be safely utilized during laparoscopic nephrectomy to achieve hemostasis during dissection. |
Nanoscale Temperature Control Mechanism in a Bipolar Vessel Sealer, Podnos, SAGES 2008 |
SAGES, April 2008, Philadelphia. Poster presentation. Yale Podnos, MD, MPH, Department of Surgery, Duke University; Peter C. Ng, MD, Wake Surgical Center, Raleigh, North Carolina; Linda SM Oleson, SurgRx, Inc. Redwood City, CA
Describes the use of an automatic temperature control mechanism in EnSeal, a bipolar vessel sealer and divider. |
Double Tap Thermography Poster, Eid, SAGES 2008 |
SAGES, April 2008, Philadelphia. Poster presentation. George Eid, M.D., Assistant Professor of Surgery, University of Pittsburgh School of Medicine.
Real time thermal footprint of a continuous power delivery technique with EnSeal as measured by high-definition thermography. Temperatures climb steadily within 10 seconds to reach 100°C, but remain steady throughout the power delivery cycle of two minutes. |
Use of a Novel Bipolar RF Device for Open and Lap Hepatic Resection |
85th World Congress of the Int'l Hepato-Pancreato Biliary Assoc, Mumbai, India, Feb. 27 - March 2, 2008. Poster presentation. Prof. Joseph Espat, M.D., Surgical Oncologist, Roger Williams Cancer Center, Providence, RI
Six hepatic parenchymal transections were performed with EnSeal. Evaluated after 30 days for postop bile leak, hepatic necrosis, or hemorrhage. No postop bile leaks, no postop drainage required in any patients, no postop hemorrhage, and no transfusions required. No parenchymal abscess noted and no transection plane necrosis. EnSeal performed without evidence of bile leak, abscess formation or change in complication rate, and performed to expected outcome standard. |
Comparison of four energy-based vascular sealing and cutting instruments - A porcine model |
Peer reviewed journal article published in Surgical Endoscopy: Comparison of four energy-based vascular sealing and cutting instruments - A porcine model. Person B, Vivas DA, Ruiz D, Talcott M, Coad JE, Wexner SD. Department of Colorectal Surgery, Cleveland Clinic, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA. (Surg Endosc. 2008 Feb;22(2):534-8. Epub 2007 Dec 20.)
Safety and efficacy study that evaluated seal strengths, speed, and acute histopathology. Instruments involved in the study were the EnSeal 5mm, LigaSure Atlas, LigaSure V, and Harmonic Ace.
Radial adventitial collagen denaturation was significantly smaller with EnSeal and LigaSure V than with the other 2 instruments; EnSeal caused less collagen denaturation than LigaSure V.
EnSeal creates significantly less thermal damage to the adventitia of the vessels and LigaSure Atlas significantly less thermal damage to the media of the vessels compared to the other instruments.
In addition to publication, information from this study was presented at a podium presentation at SAGES (2007), Las Vegas; poster presentation at EAES, Berlin, 2006; podium presentation at SLS, Boston, 2006. |
Singer Emerging Technology Poster Abstract SAGES 2007
Actual poster: Effect of a Compression Mechanism on Vessel Sealing |
SAGES, April 2007, Las Vegas Poster Presentation, Emerging Technologies: The Effect of a Compression Mechanism on Energy Based Vessel Sealing.Dr. Marc Singer, colorectal surgeon, University of Illinois, Chicago. Linda SM Oleson, Clinical Research, SurgRx, Inc.
Describes EnSeal's unique "I-Blade" compression / transection mechanism in addition to key features of EnSeal, including seal strengths, low temperatures, and minimal thermal tissue effects as evidenced by histopathology from a chronic study (Sahin, et. al.). |
Newcomb Iannitti EnSeal Abstract SAGES 2007 |
SAGES, April 2007, Las Vegas Podium Presentation: Comparison of Blood Vessel Sealing Among New Electrosurgical and Ultrasonic Devices. Dr. William L. Newcomb, Carolinas Medical Center.
Dr. Newcomb disclosed on the podium that the study was funded by LigaSure.
Comparative vessel sealing study at the Carolinas Medical Center under Dr. David Iannitti. This study evaluated the EnSeal 5mm, Gyrus PKS Cutting Forceps, Gyrus Plasma Trissector, Harmonic Scalpel, LigaSure V with Vessel Sealing Generator, LigaSure V with Triad generator, and a Ligamax Clip Applier.
In his podium presentation, Dr. Newcomb stated that EnSeal had the highest overall burst pressures of the group. He also stated at the conclusion of his presentation that they do not recommend the Gyrus instruments for laparoscopic surgery due to the high seal failure rates (over 90% in the 6-7 mm vessel size category for the Trissector). |
Comparison of Ligasure EnSeal and suture techniques in intra-abdominal adhesions |
Independent peer reviewed journal article: Comparison of Ligasure, SurgRx (EnSeal), and suture techniques in intra-abdominal adhesions that occur after liver resection in rats: an experimental study. Sahin DA1, Kusaslan R1, Sahin O2, Akbulut G1, Ozen OA3, Dilek ON1.
1Department of General Surgery, 2Pathology and 3Anatomy, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey. Published in International Surgery journal, Jan. - Feb. 2007. (Int Surg 2007; 92:20)
Evaluation of intra-abdominal adhesions after liver resection in rats using Ligasure and EnSeal. Two rat liver lobes were resected from the middle using sutures in group A, Ligasure in group B, and EnSeal in group C. Relaparotomy was performed at postoperative day 7 to evaluate intra-abdominal adhesion formation.
Adhesion formation was significantly lower in the EnSeal group compared with the suture and Ligasure groups. EnSeal and Ligasure provide effective hemostasis in liver resection without leaving foreign bodies such as clips and knots behind. EnSeal was superior to suture and Ligasure techniques in terms of adhesion formation in our model. |
Histological Effects of Bipolar Vessel Sealing Devices, Sahin |
Independent peer reviewed journal article: Histopathological Effects of Bipolar Vessel Sealing Devices on Liver Parenchyma and Comparison with Suture Method: An Experimental Study. Sahin DA1, Kusaslan R1, Sahin O2, Akbulut G1, Bas O3, Dilek ON1.
Department of General Surgery, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey. Published in European Surgical Research, March, 2007. (Eur Surg Res 2007; 39:111)
Histopathological evaluation and comparison of lateral injury during rat liver resection with EnSeal, LigaSure, and suture. The resected piece was evaluated acutely, the subjects survived for 7 days, and the remaining liver tissue was harvested and evaluated at the end of the 7 day period.
Necrosis, exudate formation, chronic inflammation, histiocytes and fibroblasts scores were significantly lower in the EnSeal group compared to both the LigaSure and the suture groups. EnSeal was superior to LigaSure in inflammatory response as it caused lower lateral thermal injury and inflammatory scores. |
ENDOSCOPIC RADIAL ARTERY - CHEST 2006, Bisleri |
CHEST Meeting, Salt Lake City, Oct. 2006. Poster presentation: Endoscopic Radial Artery Harvesting with a Novel Nanoscale Controlled Bipolar Radiofrequency Device. Bisleri G1, Hrapkowicz T2, Nozynski J3, Zembala M2, Muneretto C1
1Division of Cardiac Surgery, University of Brescia Medical School, Brescia, Italy; 2Division of Cardiac Surgery, Silesian Center for Heart Diseases, Zabrze, Poland; 3Institute of Pathology, Silesian Center for Heart Diseases, Zabrze, Poland
Sixteen patient study demonstrating the advantages of the endoscopic approach using EnSeal compared to open technique in terms of neurological impairment, vascular compromise to the hand, development of hematomas and improved aesthetics.
Conclusions: ERAH combining the EnSeal System and a reusable retractor is a feasible procedure, which shows to be safe and effective with negligible damage to the harvested conduits at histological analysis. |
Bisleri-Heart Surgery Forum, EnSeal Case Report |
Case Report, published on Heart Surgery Forum (peer reviewed online journal), June, 2006. Nanoscale Radiofrequency Control Technology for Endoscopic Radial Artery Harvesting: A Case Report. Gianluigi Bisleri, MD1, Paolo Piccoli, MD1, Tomasz Hrapkowicz, MD2, Hasan Birtan, MD2, Claudio Muneretto, MD1
1Division of Cardiac Surgery, University of Brescia Medical School, Brescia, Italy; 2Division of Cardiac Surgery, Silesian Center for Heart Diseases, Zabrze, Poland
First case reported in literature regarding the use of EnSeal for endoscopic harvesting of the radial artery.
Patient did not suffer any ischemic or neurological hand impairment and had prompt wound healing. At a 3-month follow-up, the patient did not show any residual sign of myocardial ischemia in the territory revascularized with the RA. |
A Preliminary Comparison of Mechanical Compression,Advincula, AAGL 2005 |
AAGL presentation, Chicago, 2005. A preliminary comparison of mechanical compression amongst three electrosurgical devices. Arnold Advincula, MD, Clinical Associate Professor, Department of Obstetrics and Gynecology, University of Michigan Comparative evaluation of mechanical compression (EnSeal 5mm, Gyrus PK, LigaSure Atlas).
Conclusion: EnSeal provides higher mechanical compression during blade activation than the other devices tested. |
Comparison of Lateral Thermal Spread in 4 Electrosurgical Devices, Advincula AAGL 2005 |
AAGL presentation, Chicago, 2005. Comparison of lateral thermal spread in four electrosurgical devices using real-time thermography. Arnold Advincula, MD, Clinical Associate Professor, Department of Obstetrics and Gynecology, University of Michigan
Comparative evaluation (EnSeal 5mm, Gyrus PK, LigaSure V, SonoSurg) of thermal spread and peak temperatures using infrared imaging.
Conclusion: EnSeal produces lower peak temperatures and demonstrably less thermal spread. |
EnSeal Urology Poster, Lee |
AUA 2004. Preliminary use of the EnSeal system for sealing of the dorsal venous complex during robotic-assisted laparoscopic prostatectomy. David I. Lee, Justin T. Lee, Urology Associates of North Texas, Arlington, TX
Conclusion: preliminary experience with EnSeal demonstrated hemostasis at least equal to that of the stapler. |
EnSeal SAGES_2005_Damani |
SAGES poster presentation, Florida, 2005. Comparative thermal spread of three radiofrequency bipolar vessel sealing devices. Tanuja Damani, MD, Arnold Advincula, MD, Lawrence W. Way, MD, UCSF
Comparative evaluation (EnSeal 5mm, LigaSure Atlas, LigaSure V) of thermal spread using infrared imaging.
Conclusion: EnSeal produced the least thermal spread of instruments tested. |
SAGES 2004 EnSeal Poster, Nagubandi |
SAGES poster presentation, 2004. Evaluation of a cutting-sealing bipolar instrument. Ravi Nagubandi, Duncan Turner, Bassem Safadi, Roger de la Torre, Sherry Wren, Lawrence W. Way
Review of first use of EnSeal in human cases by 5 surgeons in 9 surgeries.
Conclusion: EnSeal appears to be effective and efficient, minimizing undesirable thermal effects associated with thermal ligation devices, and shows promise as an effective multifunctional surgical tool. |
AAGL 2004 - Demonstration of Proper Technique |
AAGL presentation, San Francisco, 2004. Demonstration of proper technique for application of EnSeal bipolar vessel sealing system in gynecologic laparoscopy. Arnold Advincula, MD, Clinical Associate Professor, Department of Obstetrics and Gynecology, University of Michigan
Conclusion: preliminary data suggests that EnSeal 5mm may provide improved vessel sealing in gynecologic surgery using proper technique. |
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